Historians of science have long made note of the surprisingly high rate of suicide attempts amongst the founders of thermodynamics. On the face of it, it makes a great deal of sense; thermodynamics is a particularly grim branch of physics which (among other, much more useful things) seems to prove the inevitability and irreversibility of death. Indeed, in applying it to the entire Universe, Lord Kelvin argued that not only life itself, but all physical processes anywhere would eventually become impossible.
I admit that I am sympathetic to this view, and that I can even occasionally make myself dizzy by thinking about it too deeply. And yet, at the same time, coming from my own, individual perspective, I actually often find the idea of entropy to be comforting.
The reason is this: it is very easy, as a transgender person, to fall into the trap of thinking of yourself as a defect. This, indeed, is how broad segments of society see us and there is a tendency to internalize this view; that we are nothing more that a sort of blight upon the perfect, Platonic forms of gender; that, indeed, in a perfect world, we would not exist at all.
But thermodynamics cuts through this nonsense. It shows that on a macroscopic scale, variation is not only to be expected–but is, indeed, necessary. And further, that this variation is a much more fundamental aspect of nature than all of these illusory, macroscopic-scale forms which are ultimately nothing more than emergent properties of massive numbers of atoms. It becomes apparent that things like gender determination are nothing more than complex sequences of chemical reactions, and that in such complicated reactions, some degree of variation is almost inevitable.
I should note that I am not stating this as to make any sort of prescriptive statement; this is merely how I justify my own existence to myself.